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GLP-1s and Lasting Health (Performance & Longevity Series)

With Jim LaValle, RPh, CCN

Season 12, Episode 7 | February 5, 2026


Many people consider GLP-1s to be a groundbreaking advancement for managing weight and improving metabolic health. Yet someone’s experience with and results from a GLP-1 can vary greatly, especially if they use them without medical oversight or a comprehensive plan that includes nutrition, exercise, and lifestyle strategies. This can also affect how their body reacts when they titrate off the GLP-1 and if they’re able to maintain their results.

In this episode, Jim LaValle RPh, CCN, offers guidance for GLP-1 use at every stage for lasting optimal health, along with insights on the benefits, challenges, and proper usage.

This episode of Life Time Talks is part of our series on Performance and Longevity with MIORA.


Jim LaValle, RPh, CCN, is a clinical pharmacist, the cochair of the American Academy of Anti-Aging Medicine, the chair of the International Peptide Society, and the Chief Science Officer for Life Time.

In this episode, LaValle explains GLP-1s and how to best use them for overall health and lasting results. Insights include the following:

  • In the last several years, GLP-1s (glucagon-like peptide 1s) have been a prominent focus in health discussions, particularly for their role in weight management and metabolic health.
  • LaValle considers GLP-1s to be a significant advancement in pharmaceutical research.
  • GLP-1s help regulate glucagon, a hormone that, when unregulated, can lead to fat storage, making weight loss difficult despite lifestyle changes. They can act as a bridge to restoring metabolic function, helping individuals who are unable to lose weight through traditional methods see progress.
  • GLP-1s can help decrease hunger signals and improve insulin function, leading to better glucose regulation and reduced risk of insulin-resistance-related conditions. They may also help reduce the risk of dementia and other cognitive issues.
  • Despite the growing availability of and interest in GLP-1s — and perhaps in part because of it — there is a lot of misinformation about them. Challenges, misuse, and side effects can occur if you’re not careful about having the right medical oversight and comprehensive treatment plan in place.
  • Proper dosing of GLP-1s is crucial. Starting with low doses and slowly increasing as guided by your provider is recommended to minimize side effects and allow the body to acclimate to the medication. Ideal dosing frequency is once per week to prevent drug dependence and side effects from overlapping half-lives (this ensures the drug is processed and mobilized effectively as it can last in the body for up to six days). A thoughtful titration plan off the medication is also necessary.
  • Integrating lifestyle changes, such as healthy nutrition and regular exercise, with GLP-1 use can help maximize the benefits and minimize some risks, as well as make it easier to come off the drug and maintain results. It’s important to address other aspects of your health that may be off as well, including your stress, thyroid and sex hormone levels, and gut health.
  • Supplements like magnesium, fiber, and creatine can support the body during GLP-1 treatment.
  • The development of oral GLP-1s is underway, offering an alternative for those averse to injections.

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Transcript: GLP-1s and Lasting Health (Performance & Longevity Series)

Season 12, Episode 7  | February 5, 2026

Jamie Martin

Welcome back to Life Time Talks and our series on performance and longevity with MIORA I’m Jamie Martin. I’m here with my colleague and friend Jim LaValle. He is a clinical pharmacist, clinical nutritionist, and the chief science officer for Life Time. How are you, Jim?

 

Jim LaValle

Doing great.

 

Jamie Martin

So in this episode today, we are talking about one of the topics, I would say, that’s been dominating headlines for the last probably five years or so. I think it’s one of things that everybody’s talking about. Should I be doing them now? Like the conversation is evolving around them. So GLP ones. We know that they’re becoming more widespread in usage and for a variety of different reasons at this point. But we just want to level set. I know we talked about this in our previous season. Like what are they? What are they for? But even just in the last year or so, we’ve seen evolved thinking about how they’re applied and used in different cases for different people.

 

Jim LaValle

Yeah, I think GLP-1s are probably the next great evolution of what pharmaceutical research can actually contribute to the wellness of individuals, right? So GLP-1s help us to be able to regulate glucose and insulin, turn off the signal of glucagon. So you’re regulating glucagon, because when that switch gets stuck, you store fat, and it doesn’t matter what you do.

 

And we’ve heard that story over and over. Someone’s 15 pounds, 20 pounds, overweight, and they exercise, they diet, they sleep right, they’re in the sauna, they’re doing everything, and not a pound comes off. And that’s because the chemistry of the body isn’t allowing it to happen, and GLP-1s have provided that lifeline or that bridge to getting your metabolism back. I think there’s, with this though, I’ve also seen a lot of people still overdoing them, not understanding how to effectively create using GLP-1s, because the more you can adopt a lifestyle around that GLP-1, the healthier you’re be. And then there’s a lot of confusion on how to dose them. So some people are doing them three times a week, or they’re doing multiple micro doses, which a lot of that I wanna get to today, because there is a good way, and then there are ways that probably should be discontinued.

 

Jamie Martin

Okay, so that we definitely want to get into those things because he said like there are pros but there’s also things to be aware of if you’re in this space. So let’s start again from the beginning like we so often do just defining what GLP ones are because they are also something they’re a peptide naturally produced in our body but to your point there’s that thing that gets turned on and off so take it from there.

 

Jim LaValle

Glucagon-like peptides are there to antagonize the signal for glucagon and improve insulin function. And then that improves glucose regulation. And there’s a lot of downstream positive things that happen when you correct insulin resistance. When insulin is high, you make more adrenaline you make more noradrenaline your blood vessels get stiffer your blood pressure goes up When you’re insulin resistant you have more risk for dementia So that’s a big and that’s been real popular people talking about that and obviously GLP one receptors are also in the brain which controls food behavior.

 

So you, so there’s a lot of interesting things that are happening with GLP-1. So, glucagon-like peptides, and then there’s combination ones that have other related peptides in them like terzepotide. But the GLP-1 family helps people to, first of all, reduce their nutrient sensing. So, their nutrient sensing goes down, their food noise goes down, and that means that you’re gonna be less hungry.

 

It’s not like there’s just magic to this. There are people that will have side effects to these, and that’s why it’s important to think about, how can you incorporate them? If you’re not a diabetic, if you’re not somebody officially insulin resistant, in which there’s dosings that are done in healthcare, how can you effectively use a GLP-1? diarrhea, constipation, nausea, big, big side effects and in some cases things like raising your amylase or lipase levels which would mean pancreatitis. There’s been reports of blurred vision. I really believe that that happens when people are taking too much and they’re not maximizing the other things that they can do to make the GLP-1 have maximum benefit.

 

Jamie Martin

Okay, and we need to get into all of that because like what do you mean like what would you want them to be maximizing and we’re gonna get to all of that. You said something that I just want to make sure I understand. you said it reduce it, GLP-1, the family of them, reduce nutrient sensing. What does that mean?

 

Jim LaValle

Yeah, nutrient sensing is that thing of, I’m hungry. I’m hungry. Right. And if you’re always have nutrient sensing, if you can’t turn that down, you can never trigger yourself to go into autophagy. OK. And can’t. And autophagy is that process of clearing out your cells, maximizing kind of how your metabolism is functioning. OK. So it’s not that you don’t sense the nutrients. It’s just your brain is always has that nutrient sense switch on which keeps your metabolism in a different position, then it’s time to clean up.

 

Jamie Martin

Got it. OK, that’s really helpful clarification in that it is, in fact, different than food noise then. OK, great. So let’s talk. Let’s just start going through some of the questions that are starting to come up around this, right? Because ⁓ a lot of people think, OK, you go on a GLP-1, you have to be on it forever. How has the thinking around that evolved, even since in just the last few years, since it became more common for non-diabetic use?

 

Jim LaValle

Yes, absolutely.

 

Yeah, I think when I put together the weight loss certification course at the American Academy of Anti-Aging Medicine using GLP-1s, it was with that full thought of how can you get someone to not be necessarily reliant on them forever if they don’t want to be, right? And so the whole position now is, what else is out there that you could do at maintenance to where as you successfully hit your weight, your target goal, and now you’re titrating back down, what are some other things that could help with GLP-1 signaling? And a lot of it has to do with how you’ve changed your lifestyle. And there’s a few key nutrients that are out there that could also be helpful. So yeah, I think people now understand that they can successfully come off and maintain their weight.

 

The problem that has happened is that people got on a GLP-1 medication. And maybe they got on it without even a medical provider. They ordered a research-only peptide, and they didn’t get labs, so you don’t know whether they’re starting out with problems that they should be careful of. Because I think that’s the other danger, is they’re thinking, this is like a nutrient. No, it’s a powerful drug. And they should, you gotta respect that. And that’s why you need provider oversight on using GLP-1s. But the fact is is that when you take them and you’re using relatively high doses right away, the receptor gets dependent on that strong signal. And so when you haven’t changed your diet, haven’t changed your exercise, haven’t done some things we’re gonna talk about, then you go to get off of it when you hit your ideal weight, then you haven’t changed anything. The only thing that’s gonna happen when you stop that drug is your body’s gonna go, where is that medication at? It’s missing. It’s missing.

 

And therefore it switches back to its old way of behaving and now you gain all your way back and the only difference is most of the time people have lost some muscle that if you do this right you don’t have to lose muscle but they’ve lost muscle and when they lose muscle they’re losing their resting and injury expenditure so they get back on it and now they’re they don’t have as much lean mass on them. So it’s important that I think there’s a right way to do it if you’re trying to maximize for body composition.

 

Lose weight, not be a full-blown diabetic. There’s just some simple things that you can do.

 

Jamie Martin

And we’re gonna, like I said, we’ll get into that. One thing that I think is interesting, you’ve talked about like when people are thinking about going off their GLP-1, it’s important for them to understand why they got on it in the first place, you know, and what impacts that’s gonna have. So can you speak to that a little bit?

 

Jim LaValle

Well, I mean, in general, there are several things that can cause insulin resistance. One could be just simple nutrient deficiencies. I’m low in magnesium, I’m low in chromium, I’m low in B vitamins. I need the nutrients that make my insulin receptor function. So that’s one. Two, lack of sleep, sleep apnea can alter glucose and insulin signaling. So that’s a big one. The third would be stress. The fourth would be environmental burden.

 

Arsenic, for example, is associated with the development of, know, diabetes and insulin receptor changes. But most of the time, it’s I stopped moving and I started eating a lot. And I don’t get steps in. I can tell you it’s interesting when you think about steps. I recently bought a push mower.

 

Jamie Martin

Okay, I love it, I have one too.

 

Jim LaValle

Well, have, you know, my new house has a fairly big yard and there’s a portion of the yard that is really better if I use a push mower versus a riding mower. The other one’s wooded and you gotta have a riding mower. But I wear my Whoop. First time I push mowed the lawn, electric one, but I didn’t use the power. Really pushed. I looked at my strain score. So Whoops give you a strain score.

 

My strain score from pushing the lawnmower was equivalent to my workouts. We’ve lost that. We don’t walk to go get our mail at the end of our driveway. We jump on our golf cart. We don’t even go to the store anymore and walk the store and walk the aisles. We order our food and it gets delivered to our home. And so for a lot of folks, lack of mobility, lack of movement, lack of exercise, leads you to why you got there. And then the other one is food choices. As people get under stress, they eat more sweets, they eat more carbs, they eat more calorie-dense food that’s not necessarily nutrient-dense food, and those kind of foods signal insulin resistance. The number one inflammatory process that occurs in your body is post meal or postprandial hyperglycemia, your blood sugars go up and then they plummet and that big jump triggers inflammation and that inflammation and that glucose dysregulation starts to create the changes and when I’m releasing glucagon. By the way, if you chew your food, it actually helps to tell the hormones being released in your gut what to do.

 

So there’s that piece.

 

Jamie Martin

Yeah, the things we don’t think about, that every, literally every like kind of action that our bodies require to like process and digest and all that is having an influence on all of these pieces.

 

Jim LaValle

Exactly. And so that’s the, you know, kind of the why people got in that position to begin with.

 

Jamie Martin

Right, right. Let’s jump into a little bit of the conversation around the titrating strategies that happen because, and this gets into dosing, and I think that you wanted to talk about that specifically. Let’s start with dosing just in general, because what you’ve seen is trends and evolutions in it since this became more popular for non-diabetic and insulin-resistant use.

 

Jim LaValle

Yeah, mean, there’s been a lot of people doing all sorts of things, the way it’s been taught, I know for at least a thousand practitioners that I’ve trained in this. You want to start off at a low dose and get your body to acclimate and have less risk of side effects.

 

Jamie Martin

Right. Is that considered starting a low dose? Is that microdosing?

 

Jim LaValle

I mean, people would call it microdosing. I mean, I always kind of look at microdosing like, okay, well, yes, you’re doing less than the dose that is recommended for a diabetic. There are people that do microdosing where they’re doing even smaller amounts more frequently during the week, which they really shouldn’t be doing because they don’t understand how the drug works. you know, there’s a lot of that kind of misinformation out there. But the bottom line is you start at a modest dose. And you’re doing that to reduce side effect potential. You don’t have to be real nauseous and get GERD and you don’t have to feel constipated or get a loose stool or any of those things. And then you do that smaller dose for a few weeks and then did the person lose weight?

 

Even at, say for example, semaglutide or Ozembic, typical dose if you’re going in would be like a milligram and a half or even up to 1.8 milligrams. We started 100 micrograms, a lot smaller. So that’s a micro dose. So you started 100 micrograms, you do it for a few weeks. How are you doing? Are you losing weight? I didn’t really lose weight, but yeah, my appetite started to come down and they changed the way they’re eating a little bit. Then you increase it slightly to 250 micrograms, which is still a tenfold lower dose, right? Are you starting to lose weight? Yeah, you know what? I’m losing weight now.

 

Jamie Martin

And maybe the food noises disappear or something like that.

 

Jim LaValle

Food noise has disappeared. I’m not cautious. There are auxiliary nutrients that you take to maximize this. We’ll get to that after. But the big point to this is that if you’re losing weight at 250 micrograms a week, two to four pounds, keep it there.

 

Jamie Martin

Right. It’s doing something.

 

Jim LaValle

You don’t really want to lose weight real rapidly, increases risk of gallstones. Sometimes you’re losing lean mass that way. Even though GLP-1s do not cause lean mass loss. They support the retention of lean mass. What causes the lean mass loss is when people don’t eat. They only eat once a day on their GLP-1. So when you’re doing that reduced dose, you’ve got 250 microgram dose, your appetite’s down, you’re not interested in kind of eating as much, but it doesn’t suppress you so much that you’re only eating once a day.

 

Jamie Martin

Right, because the reality is your body still needs the nutrients to function at its most optimal.

 

Jim LaValle

Well, yeah, because when you start to lower that many nutrients, that’s why you hear about hair fall out and that kind of stuff. It’s very simple. If you don’t eat many calories, things like your hair will start to take the hit because your hair needs nutrients in order to grow ⁓ and to keep the follicle healthy. So you want to titrate to the dose that’s effective for you losing weight. And as you’re approaching your ideal weight, you would titrate off, you would start to lower the dose and then go off. That being said, if all you’ve done is do the GLP-1, when you go off, you’re gonna more than likely gain your weight back, at least some of it, because you haven’t corrected the other aspects of your chemistry, your metabolism, that could be contributing to why you weren’t able to keep that weight off in the first place.

 

Jamie Martin

Right. So let’s talk about those other aspects just to make sure that we’re covering them and being really clear about what they are.

 

Jim LaValle

Yeah, so one stress hormones, cortisol in particular. So if you’re under stress, you’re going to stress eat. So when you get rid of the GLP-1 and you’ve turned off your appetite, right? That new food noise, it’s going to start to come back if you’re under stress and you haven’t figured out how to correct for that. That’s one. Two would be thyroid hormone. Like balancing out your thyroid to make sure you’re optically metabolizing what you should be doing, generating energy.

 

The third would be sex hormones. You know, you want to look at, depending on what age you are, are you in the right spot with your hormones? If you’re a man, is your testosterone low? If you’re a woman, is your imbalances in your estrogen, progesterone, testosterone? ⁓ So that’s important. then gut health. Gut health is important because we’ve seen this over the years. People that develop food sensitivities and food allergies end up gaining weight because of the inflammation signal.

 

When anything that triggers inflammatory signaling will affect the insulin receptor. Got it. So all these other aspects that affect inflammation affect your insulin and glucose utilization, which affects glucagon. Right. Right. So ideally, you titrate so that when you go to go off,

 

Your body isn’t used to this significant large bolus of drug that’s there for six days. It’s been getting just enough to retrain it. Yep. Enough to get the appetite down enough to burn fat. And then if you’re exercising and you’re eating enough protein, lose all fat mass and very little lean mass. So you preserve your resting energy expenditure.

 

And you, goes, look, know, lean mass is the currency of living longer.

 

Jamie Martin

You need it. We need that muscle.

 

Jim LaValle

Got to have it.

 

Jamie Martin

So we can be functionally fit and mobile for the long term. That’s right. Let’s talk about how people take it. Because you mentioned there’s people who are like there might be people taking smaller doses every day or other strategies that I’m not aware of. What does that look like ideally for people? Or is it it depends type of response?

 

Jim LaValle

No, ideally they should do it once a week. Okay. Okay. As a half life. Okay. So you take the drug and it lasts for six days. First of all, there’s a critical amount that you need in order to have an effect. Secondly, if you’re doing small doses and you keep staggering the half life, one on top of the other, you get out to eight to 12 weeks and you’ve got all these layered half lives of all these injections, you could find yourself with some side effects. Right?

 

Jamie Martin

Why is that important?

 

Jim LaValle

As this, so, you know, it’s the same thing with doing it. Like some people are doing it. Oh, I do it two times a week or do it three times a week. Not even every day. That’s the same thing. You’re not allowing for the drug to be processed and mobilized. Instead, you’re creating more dependence.

 

Jamie Martin

So later going off could be even more difficult. It’s interesting because I actually just had a situation in my life where someone was telling me they were starting this and their recommended provider they were working with was like, no, you’re going to do a daily dose. I’m like, that’s really interesting. I had never heard it. I was like, I have not heard about that. So I’m excited that we’re having this conversation.

 

Jim LaValle

Exactly.

 

Yeah, I mean, just, once again, you know, got to follow the, what’s called the pharmacokinetics. Like what’s going on when you take this? The drug has a long half life. Therefore you don’t want to be stacking doses one on top the other. Now what I will say is that there are some people that they kind of get stuck at their 250 microgram dose or 500 microgram dose. And what we’ve done here and there is say, you know what, for a couple of weeks, cut it in half and do it twice a week for a couple of weeks just to change it, but then get back to your normal dosing. And a lot of times that will liberate that stick point that occurred.

 

Jamie Martin

But really what you’re saying is once a week is ideal, twice a week if you’re at like a certain point in the process.

 

Jim LaValle

A stick point for a short period of time.

 

Jamie Martin

Okay.

 

Jim LaValle

Short period of time.

 

Jamie Martin

Okay, I like love all these caveats and nuances that there are that we’re talking about ⁓

 

Jim LaValle

And you could do the more, mean, the oral ones are gonna come out with greater bioavailability now. I mean, there’s a couple of new ones that are on the way out that are oral and do as good a job as the injectable. So I think we’re gonna see the market shift. Some people just don’t like needles.

 

Jamie Martin

Yeah, well, and that’s going to be a thing that prevents them, right?

 

Jim LaValle

That’s legitimate. I don’t like to stick myself with a needle, okay? But the oral GLP ones, there’s some that have been out, right? But they typically top people off at about 10 to 15 pounds of weight loss. You don’t get into any more than that. But the new ones, the new generation of them coming out that are oral actually work pretty effectively to drop a significant amount of weight.

 

Jamie Martin

Those, have any of those been FDA approved yet?

 

Jim LaValle

No, they’re process. One’s in a phase, I think 3A now, orforglipron. Orforglipron is a small molecule. So it’s not a peptide, it’s a small molecule, but it acts as a GLP-1. So there’s really cool things on the horizon related to this. Super interesting. And you know, look, 50% of our U.S. population is either insulin resistant or diabetic. Right. One in two people.

 

So why are we seeing this momentum? Well, because a lot of our population has this issue and that does not include the person that may not be categorized there or now that they’re approved for obesity. They may not be obese, but they can’t get the last 15 or 20 pounds off no matter what they do. And that extra weight is actually influencing their metabolism. it’s, know, if it’s, it could be 10 or 20 pounds.

 

And it could be affecting a wide range of what’s going on with their health. And so the point being, think I like the Orals coming out because I think they’re going to be even more significant. Probably 80% of the U.S. population has more weight on them than they should have. they can’t get that last 15 pounds off no matter what they do. Body image goes, self-esteem’s down, chemistry’s off, right? So they have all kind of the, hey, my blood sugar’s just a little bit up, my lipids are a little bit off. And it’s important we service those folks too. So that’s why this is, it’s like a wildfire of desire to get this out into the market. And we’re seeing the government saying, let’s slash the prices of these things so that we can get it in more hands of people.

 

I know from, we knew about this, mean, by teaching this to physicians are you know a full thought of what you need to control like I went through right? Of course I’ll all theirs But there’s baseline things people should do if they’re going to be on a GLP-1, right? One they should take magnesium and let’s say I have a loose stool If you’re gonna lose stool magnesium is gonna make you continue to have a loose right? So but in general people get tend to get constipated more than get a loose stool, right? And in that case taking magnesium is really good. I’m taking fiber Really good for people that are on a GLP-1.

 

Creatine, really like creatine, five to 10 grams a day, help to maintain lean mass. And then the fourth would be if you have a lot of weight to lose and you’re, I like supporting the liver and the gallbladder to kind of help process the fat and that’s using compounds like artichoke extract, bergamot extract. And then from there it’s getting enough protein in. But that’s the key. Those things are the ones that we use all the time. If I’m real concerned about lean mass, the peptide that we’ve talked about, sermorelin, sermorelin is a growth hormone secretiog. People take it five days out of seven, but it helps maintain the lean mass, but more importantly, skin laxity.

 

So as you’re losing weight, you wanna keep that skin integrity good. And sermorelin does a great job of helping to maintain skin integrity, maintain lean muscle mass. And I just talked with Cliff Edberg, who’s really instrumental in what we’re doing with MIORA at Life Time. And the people that we’re doing these programs with are losing virtually no lean mass. And that’s because we have them exercising, they’re doing the right diet, we’re making sure they hit their protein targets. We make sure that they, many of them are using sermorelin, unless they have a history of cancer, you don’t use sermorelin. And then keep your bowels moving and keep the magnesium up because that’s gonna keep the energy up in your muscle.

 

Jamie Martin

So I just want to make sure I’m understanding. So you’re saying in addition to like the GLP-1 and whatever, like the kind of individualized dosing for you, you may also recommend sermorellin for the muscle piece of it, if it makes sense for someone.

 

Jim LaValle

Exactly. Yeah. Yeah. And creatine. Because in the end, the more you can restore muscle, right? Gain lean muscle if possible, because the better you’re training, the better your metabolism will be, right? So you have to have that thought of if you just want to do the drug, I get that. Been around that for, you they’ve been out for 20 years. It’s nothing new. But if you’re wanting to do this because of health goals, performance, health, and longevity. Performance health isn’t just about how hard you’re working out in the gym. Well, how effective are you at work and how good do you feel?

 

Jamie Martin

How do you show up in all aspects of your life, right?

 

Jim LaValle

Exactly. So if that’s the goal of getting on it, then it really helps to do the auxiliary or accessory things that are going to help you guarantee that there’s an off ramp. And then what do you do when you’re on the off ramp?

 

Jamie Martin

Right. And I think that’s the, you know, it’s like maintaining those habits. And are there, are you seeing instances where even with the off-ramp that’s super thoughtful, do people end up going back on? What are you seeing in terms of like returning to it potentially?

 

Jim LaValle

Yeah, you see both. Okay. I mean, there’s people that just honestly, they do better on a little bit of it. They just do and okay.

 

Jamie Martin

And would that be considered in that case, right? I’m on rep I just have that little bit just to kind of keep maybe the food noise down or whatever that thing is for you, right?

 

Jim LaValle

That’s exactly right. Okay. Yeah, keep it moving. you know, I think I’ve always talked to this with, you know, when this first came out, you and I talked about this before we got on the show was, you know, there’s such a negative connotation to it when it first came around that it was like, that’s cheating. You just exercise more and eat better. You’re going to gain. Problem is a lot of people did that. It didn’t happen. Yep.

 

And you know, we never turn away people’s need for insulin, which is a pancreatic hormone that your body needs in order to live. So you wouldn’t say to somebody, insulin’s a peptide. You know, that’s cheating. No, because if they didn’t take their insulin, they could have an acute situation. They don’t live real long. They’re a type one diabetic taking insulin. GLP-1s are a hormone that affects the pancreas and the utilization of energy and storage of energy. you don’t fix that, people just end up succumbing to a lot of other problems like heart failure, kidney disease, progression of their diabetes, cognitive issues. And so they kind of erode slowly. So why would you think about that’s not a shortcut, it’s you’re giving people hope.

 

Jamie Martin

Well, and you’re rebalancing chemistry, right? And I think that’s one of the things over the last year and mean, you’re right. When I, I remember three to four years ago when we really started coming into the mainstream, I was like, oh my gosh, that’s a quick fix. And really as more information has come out, as we’ve had more conversations, as MIORA at Life Time has become a bigger thing, thinking of them as kind of this tool in the toolkit that really is about chemistry, really, like getting that chemistry back in order so we can, so the other things we’re doing in our daily life actually do have the impacts that they’re intended to have.

 

Jim LaValle

In the end, you said that beautifully because in the end, why I love pharmacy, and I’ve had other degrees and have studied a lot of things in my life, but why I love my pharmacy training is that whether it’s an emotion, a scent, a drug, a nutrient, a food, all of them are chemistry altering. And so you use whatever tools you have to allow the signaling of your biochemistry to become unified again. That’s the goal. GLP-1s, one of the biggest things to happen in the last decade in terms of for, not just for diabetes, it’s been around for 20 years, but in terms of weight loss and people getting back to being healthy, I can’t think of a more significant invention that’s out in the market right now.

 

Jamie Martin

Right. Well, and to that point, I mean, we’re talking about it kind of in the context of body composition and weight management and all of those pieces, but there is also some, you know, there’s some headlines out there about the other effects that it could be having, kind of the unexpected and complementary effects that it could be having on health. Can you just briefly speak to that?

 

Jim LaValle

Well, we know that it has a big role in cognitive function that it down regulates microglial cells in the brain, which are your immune cells in your brain. When they get active, they start kicking out a lot of oxidative compounds that damage your neurons, leads to memory loss. And so there’s some real hope that that’s going to protect the brain. Interestingly, will microdosing it have the same effect as in the clinical trials when they were doing the full doses?

 

For people with diabetes, because we always have to remember, once you’re a person with diabetes, your chemistry is way different than a person is not. But do I think it’s gonna have value there? Yes. Do I think there’s some, there’s people that get less anxious and nervous and moods get better from being on a GLP-1, so it’s being applied there. So all of those areas are of benefit. And the biggest thing is understanding, am I a candidate?

 

If I’m going to do this, create a full program around it so that I can really maximize my results and get out of it what you deserve. Right. Is that restoration to being.

 

Jamie Martin

Right. And we would really recommend also doing that with a support team, healthcare provider and other supports as needed.

 

Jim LaValle

I think it’s the way that you get to the end of it and the off-ramp is you have your healthcare providers are overseeing, is making sure everything’s okay. You do your next blood test, oh wow, your liver enzymes are good, you’re not making lipase, not making amylase, your insulin’s better, your glucose is better, right? All those good things happen. And then it’s also accountability walking into the gym. And it’s also accountability because you’re talking to a dietitian and it’s creating that team that’ll allow you to be successful if you’re going to go down the path of a GOP one.

 

Jamie Martin

All right, well, we covered a lot of ground here again in this episode. If people want to learn more, we’ve had a couple of live stream sessions that we’ve done. Those are available in the Life Time app. They can also learn more at miora.lifetime.life. All right, thanks, Jim.

 

Jim LaValle

Great to be here.

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The information in this podcast is intended to provide broad understanding and knowledge of healthcare topics. This information is for educational purposes only and should not be considered complete and should not be used in place of advice from your physician or healthcare provider. We recommend you consult your physician or healthcare professional before beginning or altering your personal exercise, diet or supplementation program.

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